Doncaster Rovers and Portsmouth are both odds against to claim the three points at the Keepmoat on Saturday.
Ladbrokes have Rovers at 13/8 to win and possibly keep alive their slim survival hopes.
Portsmouth are also desperate for a win to avoid dropping into League One and they are the slight favourites at 6/4.
A draw would send Rovers down and could possibly send Portsmouth down depending on how Bristol City do at Birmingham and it is 12/5 on the draw.
Rovers are once again suffering an injury crisis and they will be hoping Chris Brown can continue in attack.
The striker failed a fitness test ahead of the game with Burnley on Monday but with Rovers down to the bare bones played and levelled the scores with his second goal in four games since returning from injury.
Brown is 7/1 to open the scoring for Rovers.
Youngster Fabian Robert is once again expected to start and he is 10/1 to score the first goal.
Dave Kitson scored the opener in the corresponding game last season for Portsmouth and he is 8/1 to score first.
Joel Ward was also on target in their 2-0 win at the Keepmoat last season and he is 18/1 to open the scoring.
For a full list of odds go to Ladbrokes .
*Odds subject to fluctuation and correct at time of print.
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